eIF4A3-IN-18
Names
[ CAS No. ]:
1402931-84-3
[ Name ]:
eIF4A3-IN-18
Biological Activity
[Description]:
eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1].
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C29H28N2O6
[ Molecular Weight ]:
500.54