p38-α MAPK-IN-5

Names

[ CAS No. ]:
1443242-46-3

[ Name ]:
p38-α MAPK-IN-5

Biological Activity

[Description]:

p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[Target]

p38α:0.1 nM (IC50)

p38β:0.2 nM (IC50)

p38γ:944 nM (IC50)

p38δ:4100 nM (IC50)


[References]

[1]. Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192.

Chemical & Physical Properties

[ Molecular Formula ]:
C37H49N11O2

[ Molecular Weight ]:
679.86

Related Compounds