5'-Protected 2,2'-anhydrouridine

Names

[ CAS No. ]:
173170-12-2

[ Name ]:
5'-Protected 2,2'-anhydrouridine

[Synonym ]:
5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil
2,2'-anhydro-5'-O-(4,4'-dimethoxytrityl)uridine
2,2'-O-anhydro-5'-O-(4,4'-dimethoxytrityl)(β-D-arabinofuranosyl)uracil
2,2'-O-anhydro-1-[5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]uracil
5'-O-(4,4'-dimethoxytrityl)-2,2'-anhydrouridine
5'-O-dimethoxytrityl anhydrouridine

Biological Activity

[Description]:

5'-Protected 2,2'-anhydrouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H28N2O7

[ Molecular Weight ]:
528.55

[ Exact Mass ]:
528.19000

[ PSA ]:
101.27000

[ LogP ]:
3.28850

Related Compounds