HDAC-IN-43

Names

[ CAS No. ]:
1809163-24-3

[ Name ]:
HDAC-IN-43

Biological Activity

[Description]:

HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC1:82 nM (IC50)

HDAC2:358 nM (IC50)

HDAC3:45 nM (IC50)

HDAC6:24 nM (IC50)

HDAC8:1441 nM (IC50)

HDAC10:182 nM (IC50)

HDAC11:9061 nM (IC50)


[In Vitro]

HDAC-IN-43 demonstrats broad anti-cancer activities against 38 cancer cell lines at 72 hours [1]. Cell Viability Assay Cell Line: K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2[1] Concentration: 0.22-1.42 μM Incubation Time: 72 h Result: showed anti-cancer activities, the IC50 values of K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2 are 0.22-1.42 μM[1].

[References]

[1]. Dizhong Chen, et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H28N6O4

[ Molecular Weight ]:
440.50

Related Compounds