Antifungal agent 35

Names

[ CAS No. ]:
2085274-00-4

[ Name ]:
Antifungal agent 35

Biological Activity

[Description]:

Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Antifungal agent 35 (compound 24) (0.0015-15 mM; C. albicans) inhibits fungal cell growth in a dose-dependent manner with EC50 value of 0.001 µM in the presence of fluconazole[1]. Antifungal agent 35 (compound 24) (0.0015-15 mM; C. albicans) shows potent activities (EC50 < 1 μM) against all resistant isolates in the presence of fluconazole[1].

[References]

[1]. Mood AD, et, al. Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida albicans. ACS Med Chem Lett. 2017 Jan 11;8(2):168-173.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H27BrN4O4

[ Molecular Weight ]:
539.42

Related Compounds