SIRT5 inhibitor 3

Names

[ CAS No. ]:
2128651-12-5

[ Name ]:
SIRT5 inhibitor 3

Biological Activity

[Description]:

SIRT5 inhibitor 3 (compound 46) is a potent and competitive SIRT5 inhibitor with an IC50 value of 5.9 μM. SIRT5 inhibitor 3 can inhibit SIRT5 desuccinylation. SIRT5 inhibitor 3 can be used for researching cancer and neurodegenerative diseases[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Research Areas >> Neurological Disease

[Target]

SIRT5:5.9 μM (IC50)


[References]

[1]. Wang Y, et al. Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem. 2022;236:114363.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H12FN3O4

[ Molecular Weight ]:
401.35

Related Compounds