Topoisomerase II inhibitor 12

Names

[ CAS No. ]:
2304527-20-4

[ Name ]:
Topoisomerase II inhibitor 12

Biological Activity

[Description]:

Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[In Vitro]

Topoisomerase II inhibitor 12 (Compound 8c) shows anti-proliferative activities with IC50 values of 8.80 ± 0.12, 7.13 ± 0.20, 6.56 ± 0.15, 10.99 ± 0.23, 10.71 ± 0.03 and 13.27 ± 0.32 μM against HepG2, HCT116, MDA-MB-231, Hela, K562 and PDLSC cells, respectively[1].

[References]

[1]. Xie XW, et al. Design, synthesis, bioevaluation of LFC- and PA-tethered anthraquinone analogues of mitoxantrone. Bioorg Chem. 2020 Aug;101:104005.

Chemical & Physical Properties

[ Molecular Formula ]:
C40H63N3O4

[ Molecular Weight ]:
649.95

Related Compounds