JNK3 inhibitor-2

Names

[ CAS No. ]:
2366264-18-6

[ Name ]:
JNK3 inhibitor-2

Biological Activity

[Description]:

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> MAPK/ERK Pathway >> JNK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor

[Target]

JNK1:>100 μM (IC50)

JNK2:>100 μM (IC50)

JNK3:0.25 μM (IC50)


[In Vitro]

JNK3 inhibitor-2 (compound J46) shows 30% and 60% inhibition to JNK2α2 at 30 μM and 100 μM, respectively[1]. JNK3 inhibitor-2 shows inhibitory ability for DDR1 and EGFR (T790M, L858R) with IC50s of 0.16, 0.37 µM, respectively[1].

[References]

[1]. Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H14N2O2

[ Molecular Weight ]:
314.34

Related Compounds