Topoisomerase I inhibitor 7

Names

[ CAS No. ]:
2408639-81-4

[ Name ]:
Topoisomerase I inhibitor 7

Biological Activity

[Description]:

Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor drug candidates among the heteroarene-fused anthraquinones[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Tikhomirov AS, et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties. Eur J Med Chem. 2020 Aug 1;199:112294.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H19N3O5

[ Molecular Weight ]:
405.40

Related Compounds