HSP90-IN-12

Names

[ CAS No. ]:
2408643-60-5

[ Name ]:
HSP90-IN-12

Biological Activity

[Description]:

Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Miura K,et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H36O4

[ Molecular Weight ]:
400.55

Related Compounds