A3AR antagonist 1

Names

[ CAS No. ]:
2413257-74-4

[ Name ]:
A3AR antagonist 1

Biological Activity

[Description]:

A3AR antagonist 1 (compound 17) is a potent and selective human A3 adenosine receptor (AR) antagonist, with an Ki of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A3 AR even at high concentrations[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

hA3:4.63 nM (Ki)


[References]

[1]. Abdelrahman A, et, al. Substituted 4-phenylthiazoles: Development of potent and selective A 1, A 3 and dual A 1/A 3 adenosine receptor antagonists. Eur J Med Chem. 2020 Jan 15;186:111879.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H24N4O4S

[ Molecular Weight ]:
560.62

Related Compounds