CDK7-IN-11

Names

[ CAS No. ]:
2414896-32-3

[ Name ]:
CDK7-IN-11

Biological Activity

[Description]:

CDK7-IN-11 is an orally active CDK7 inhibitor. CDK7-IN-11 exhibits high CDK7 inhibitory activity with IC50 value of 4.2 nM. CDK7-IN-11 can be effectively used for the research of diseases associated with CDK7[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK7:4.2 nM (IC50)


[In Vitro]

CDK7-IN-11 (example 5) has inhibitory activity for CDK7 with IC50 value of 4.2 nM[1]. CDK7-IN-11 (72 h) inhibits cell proliferation in MDA-MB-468 cells and HepG2 cells with IC50 values of 14.0 nM and 3.0 nM[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-468 cells, HepG2 cells Concentration: Incubation Time: 72 h Result: Showed antiproliferative effect in cells.

[References]

[1]. Novel cdk7 inhibitory compound or pharmaceutically acceptable salt thereof. Patent. WO2021182914A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H28N6O2S

[ Molecular Weight ]:
488.60

Related Compounds