DNA Gyrase-IN-5

Names

[ CAS No. ]:
2417016-23-8

[ Name ]:
DNA Gyrase-IN-5

Biological Activity

[Description]:

DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.10 μM (DNA gyrase)[1]


[In Vitro]

DNA Gyrase-IN-5 (Compound 8I-w) shows antibacterial activities with IC50 values of 4.7, 7.0, 17.0, 13.5, 1.0, 25.3 and 47.8 μM against E. coli, E. coli E564, E. coli E68, E. coli E48, E. coli E109, Salmonella and S. aureus, respectively[1].

[References]

[1]. Liu H, et al. Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase. Bioorg Chem. 2020 Jun;99:103807.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H15BrClN5

[ Molecular Weight ]:
500.78

Related Compounds