CDK4/6-IN-12

Names

[ CAS No. ]:
2445205-24-1

[ Name ]:
CDK4/6-IN-12

Biological Activity

[Description]:

CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4:592.3 nM (IC50)

CDK6:3090 nM (IC50)


[In Vitro]

CDK4/6-IN-12 (compound 4a) inhibits CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively[1].

[References]

[1]. Chen Shi, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H10N6

[ Molecular Weight ]:
238.25

Related Compounds