HDAC-IN-42

Names

[ CAS No. ]:
2454024-18-9

[ Name ]:
HDAC-IN-42

Biological Activity

[Description]:

HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC1:0.19 μM (IC50)

HDAC6:4.98 μM (IC50)


[In Vitro]

HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 µM for MCF-7, HCT-116, HepG2, Hela cells, respectively[1]. HDAC-IN-42 (1, 5, 10 µM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells[1]. HDAC-IN-42 (1, 5, 10 µM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase[1].

[References]

[1]. Ding J, et al. Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities. Bioorg Chem. 2020 Aug;101:104023.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H15NO7

[ Molecular Weight ]:
381.34

Related Compounds