DNA topoisomerase II inhibitor 1
Names
[ CAS No. ]:
2459950-15-1
[ Name ]:
DNA topoisomerase II inhibitor 1
Biological Activity
[Description]:
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase[1].
[Related Catalog]:
[In Vitro]
DNA topoisomerase II inhibitor 1 (compound 8ed) (0-10 µM; 48 h) shows cytotoxic activity with IC50s of 10.10, >10, 0.59, 4.20, >10, >10, 8.41 µM for HT-29, MDA-MB-231, MG-63, U87MG, PC3, HeLa, Vero cells, respectively[1]. DNA topoisomerase II inhibitor 1 (0.5, 2 µM; 24 h) induces apoptosis and cell cycle arrest at sub G1 phase[1]. DNA topoisomerase II inhibitor 1 (0.5, 2 µM) increases the generation of reactive oxygen species (ROS)[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C28H24N4O3S
[ Molecular Weight ]:
496.58