Topoisomerase I inhibitor 4

Names

[ CAS No. ]:
2485135-31-5

[ Name ]:
Topoisomerase I inhibitor 4

Biological Activity

[Description]:

Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

IC50: 1.20 μM (HepG2), 2.09 μM (A549), 1.56 μM (MCF-7), 1.92 μM (HeLa)[1]


[In Vitro]

Topoisomerase I inhibitor 4 (1-80 μM) shows Top1 inhibitory activity[1]. Topoisomerase I inhibitor 4 (0-40 μM; 48 h) inhibits proliferation of cancer cells[1]. Cell Proliferation Assay[1] Cell Line: HepG2, A549, MCF-7 and HeLa cell lines Concentration: 0-40 μM Incubation Time: 48 hours Result: Showed antiproliferative activities to HepG2, A549, MCF-7 and HeLa cells with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively.

[References]

[1]. Xiang, Y, et al. Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors. Med Chem Res 30, 1512–1522 (2021).

Chemical & Physical Properties

[ Molecular Formula ]:
C23H19FN4O

[ Molecular Weight ]:
386.42

Related Compounds