Topoisomerase II inhibitor 8

Names

[ CAS No. ]:
2493298-68-1

[ Name ]:
Topoisomerase II inhibitor 8

Biological Activity

[Description]:

Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC50 of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase II:0.52 μM (IC50)


[References]

[1]. Abbass EM, et, al. Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers. Bioorg Chem. 2020 Nov;104:104255.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H8N4O3S

[ Molecular Weight ]:
312.30

Related Compounds