BRAF V600E/CRAF-IN-1

Names

[ CAS No. ]:
2499499-56-6

[ Name ]:
BRAF V600E/CRAF-IN-1

Biological Activity

[Description]:

BRAF V600E/CRAF-IN-1 (Compound 8b) is a potent inhibitor of BRAF V600E/CRAF. BRAF V600E/CRAF-IN-1 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-1 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[References]

[1]. El-Damasy AK, et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H17F6N3O2

[ Molecular Weight ]:
505.41

Related Compounds