BRAF V600E/CRAF-IN-2

Names

[ CAS No. ]:
2499499-62-4

[ Name ]:
BRAF V600E/CRAF-IN-2

Biological Activity

[Description]:

BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[References]

[1]. El-Damasy AK,et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H30F3N5O2

[ Molecular Weight ]:
549.59

Related Compounds