DENV-IN-7

Names

[ CAS No. ]:
2499537-22-1

[ Name ]:
DENV-IN-7

Biological Activity

[Description]:

DENV-IN-7, a flavone analog, is a dengue virus (DENV) inhibitor with an EC50 value of 70 nM. DENV-IN-7 has low toxicity against normal cell and anti-dengue activity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

DENV-IN-7 (compound 5d; 10 μM; 48 h) 对 LLC/MK2 细胞具有低毒性[1]。 DENV-IN-7 (1 nM-10 μM; 72 h) 具有抗登革热活性，并抑制 DENV2 感染的 LLC/MK2 细胞中的病毒复制[1]。 Cell Viability Assay[1] Cell Line: LLC/MK2 cells Concentration: 10 μM Incubation Time: 48 hours Result: Had non-toxic with the viability above 75%.

[References]

[1]. Patigo A, et, al. Design, synthesis, in vitro, in silico, and SAR studies of flavone analogs towards anti-dengue activity. Sci Rep. 2022 Dec 14;12(1):21646.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H22O8

[ Molecular Weight ]:
438.43

Related Compounds