DNA Gyrase-IN-2

Names

[ CAS No. ]:
2522666-80-2

[ Name ]:
DNA Gyrase-IN-2

Biological Activity

[Description]:

DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC50s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Mohamed A Omar, et al. Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity. Bioorg Chem. 2020 Nov;104:104316.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N8OS2

[ Molecular Weight ]:
504.63

Related Compounds