Adenosine receptor inhibitor 2

Names

[ CAS No. ]:
2550401-76-6

[ Name ]:
Adenosine receptor inhibitor 2

Biological Activity

[Description]:

Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

A1AR:52.2 ± 8.5 nM (Ki)

A2AR:167 ± 22 nM (Ki)

hA2B:>1000 nM (Ki)

Adenosine A3 receptor:>1000 nM (Ki)


[References]

[1]. Załuski M, et al. 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation. Bioorg Chem. 2020 Aug;101:104033.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H20BrN5O2

[ Molecular Weight ]:
406.28

Related Compounds