Synstab A

Names

[ Name ]:
Synstab A

Biological Activity

[Description]:

Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

α-Tubulin and β-Tubulin interaction[1]

[References]

[1]. Gerry CJ, et al. Unifying principles of bifunctional, proximity-inducing small molecules. Nat Chem Biol. 2020 Apr;16(4):369-378.

[2]. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.

Chemical & Physical Properties

[ Density]:
1.73g/cm3

[ Molecular Formula ]:
C₁₅H₁₃BrCl₃N₃O₃S

[ Molecular Weight ]:
501.61

[ Exact Mass ]:
498.89300

[ PSA ]:
109.67000

[ LogP ]:
5.87970

[ Index of Refraction ]:
1.663