Neuraminidase-IN-2

Names

[ CAS No. ]:
2599015-44-6

[ Name ]:
Neuraminidase-IN-2

Biological Activity

[Description]:

Neuraminidase-IN-2 is an anti-influenza compounds with IC50 values of 0.28, 0.27, 11.50, 0.089 and 23.44 µM for H1N1, 09H1N1, H3N2, H5N1 and H5N2, respectively. Neuraminidase-IN-2 has antiviral activity and low cytotoxicity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[In Vivo]

Neuraminidase-IN-2 (Compound 5c) (1 g/kg；灌胃；单剂量) 对小鼠毒性较低，不显著增加小鼠的体重[1]。

[References]

[1]. Jia R, et al. Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity. Eur J Med Chem. 2021 Feb 15;212:113097.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H38N2O6

[ Molecular Weight ]:
510.62

Related Compounds