CDK4/6-IN-9

Names

[ CAS No. ]:
2688098-02-2

[ Name ]:
CDK4/6-IN-9

Biological Activity

[Description]:

CDK4/6-IN-9 (compound 10) is a selective CDK4/6 inhibitor with an IC50 of 905 nM for CDK6/cyclin D1. CDK4/6-IN-9 has the potential for multiple myeloma (MM) research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK6/cyclinD1:905 nM (IC50)

CDK4/cyclinD1


[References]

[1]. Kai Yuan, et al. Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma. Eur J Med Chem. 2022 Jan 15;228:114024.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23FN8

[ Molecular Weight ]:
418.47

Related Compounds