5’-Azido-2’,5’-dideoxyuridine

Names

[ CAS No. ]:
35959-37-6

[ Name ]:
5’-Azido-2’,5’-dideoxyuridine

[Synonym ]:
5'-N3-2'-dU
5'-Azido-2'-deoxyuridine
5'-azido-2',5'-dideoxyuridine
Uridine,5'-azido-2',5'-dideoxy

Biological Activity

[Description]:

5’-Azido-2’,5’-dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H11N5O4

[ Molecular Weight ]:
253.21

[ Exact Mass ]:
253.08100

[ PSA ]:
134.33000

Synthetic Route

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