3’-Deoxy-3’-α-C-methylguanosine

Names

[ Name ]:
3’-Deoxy-3’-α-C-methylguanosine

[Synonym ]:
3'-Deoxy-3'-methylguanosine
Guanosine, 3'-deoxy-3'-methyl-

Biological Activity

[Description]:

3’-Deoxy-3’-α-C-methylguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Molecular Formula ]:
C₁₁H₁₅N₅O₄

[ Molecular Weight ]:
281.27

[ Exact Mass ]:
281.112396

[ LogP ]:
-0.23

[ Index of Refraction ]:
1.856