3’-O-(t-Butyldiphenylsilyl) thymidine

Names

[ CAS No. ]:
83467-48-5

[ Name ]:
3’-O-(t-Butyldiphenylsilyl) thymidine

[Synonym ]:
2'-deoxy-3'-tert-butyldiphenylsilyl-thymidine
3'-O-(t-butyldiphenylsilyl)thymidine
3'-O-(tert-butyldimethylsilyl)adenosine
3'-O-tert-butyldiphenylsilyl-2'-deoxythymidine
O3'-(tert-butyl-dimethyl-silanyl)-adenosine
3'-O-(tert-butyldiphenylsilyl)thymidine
1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
3'-O-TBDPS-thymidine

Biological Activity

[Description]:

3’-O-(t-Butyldiphenylsilyl) thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H13DTBN2O5PS

[ Molecular Weight ]:
320.10

[ Exact Mass ]:
480.20800

[ PSA ]:
93.81000

[ LogP ]:
2.48230

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream