3′-Bromo-3′-deoxythymidine

Names

[ CAS No. ]:
99785-51-0

[ Name ]:
3′-Bromo-3′-deoxythymidine

[Synonym ]:
Thymidine,3'-bromo-3'-deoxy
3'-Br-ddT
3'-Bromo-2',3'-dideoxythymidine

Biological Activity

[Description]:

3′-Bromo-3′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H14BrNO4

[ Molecular Weight ]:
304.14

[ Exact Mass ]:
304.00600

[ PSA ]:
84.58000

[ LogP ]:
0.30060

Related Compounds