7,3',4'-Trihydroxy-3-benzyl-2H-chroMene

Names

[ Name ]:
7,3',4'-Trihydroxy-3-benzyl-2H-chroMene

[Synonym ]:
4-[(7-Hydroxy-2H-chromen-3-yl)methyl]-1,2-benzenediol
W2750
1,2-Benzenediol, 4-[(7-hydroxy-2H-1-benzopyran-3-yl)methyl]-
7,3',4'-Trihydroxy-3-benzyl-2H-chromene

Biological Activity

[Description]:

7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[Target]

IC50: 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5 µM [H9N2][1].

[In Vitro]

7,3',4'-Trihydroxy-3-benzyl-2H-chromene 具有有效的 NAs 抑制活性，IC50 值分别为 34.6 µM [H1N1]、39.5 µM [ H3N2] 和 50.5 µM [H9N2][1]。

[References]

[1]. Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35(5):786-90.

[2]. Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62(3):325-7.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
540.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄O₄

[ Molecular Weight ]:
270.280

[ Flash Point ]:
280.9±30.1 °C

[ Exact Mass ]:
270.089203

[ PSA ]:
69.92000

[ LogP ]:
3.24

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.702

Safety Information

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%