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PHM-27 (human)

Names

[ CAS No. ]:
118025-43-7

[ Name ]:
PHM-27 (human)

[Synonym ]:
phm,human
h-his-ala-asp-gly-val-phe-thr-ser-asp-phe-ser-lys-leu-leu-gly-gln-leu-ser-ala-lys-lys-tyr-leu-glu-ser-leu-met-nh2
peptide histidine methionine,human
his-ala-asp-gly-val-phe-thr-ser-asp-phe-ser-lys-leu-leu-gly-gln-leu-ser-ala-lys-lys-tyr-leu-glu-ser-leu-met-nh2
m.w. 2985.41 c135h214n34o40s

Biological Activity

[Description]:

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CGRP Receptor
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Neuronal Signaling >> CGRP Receptor
Research Areas >> Metabolic Disease

[Target]

EC50: 11 nM (human calcitonin receptor)[2]


[References]

[1]. N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9.

[2]. Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84.

[3]. I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C135H214N34O40S

[ Molecular Weight ]:
2985.41000

[ Exact Mass ]:
2983.55000

[ PSA ]:
1234.12000

[ LogP ]:
2.92740

Related Compounds