CV 1808
Names
Biological Activity
[Description]:
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[In Vitro]
CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM[1]. In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM[2].
[In Vivo]
Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles[3]. Animal Model: Male Sprague-Dawley rat, weighing 370-410 g[3] Dosage: 0.002, 0.02, 0.2, and 2 μM Administration: Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808 Result: Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
[References]
Chemical & Physical Properties
[ Density]:
1.78g/cm3
[ Boiling Point ]:
766ºC at 760mmHg
[ Melting Point ]:
210-212ºC
[ Molecular Formula ]:
C16H18N6O4
[ Molecular Weight ]:
358.35
[ Flash Point ]:
417.1ºC
[ Exact Mass ]:
358.13900
[ PSA ]:
151.57000
[ LogP ]:
0.41780
[ Index of Refraction ]:
1.829
[ Storage condition ]:
−20°C
[ Water Solubility ]:
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.6 mg/mL
Safety Information
[ WGK Germany ]:
3