Syntide 2 trifluoroacetate salt

Names

[ Name ]:
Syntide 2 trifluoroacetate salt

[Synonym ]:
CALMODULIN-DEPENDENT PROTEIN KINASE SUBSTRATE
CA2+/CALMODULIN KINASE II SUBSTRATE
H-PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-ALA-GLY-LEU-PRO-GLY-LYS-LYS-OH
PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-ALA-GLY-LEU-PRO-GLY-LYS-LYS
PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-GLY-LEU-PRO-GLY-LYS-LYS
SYNTIDE-2 [PLARTLSVAGLPGKK]
Syntide2calmodulin-dependentproteinkinase
PLARTLSVAGLPGKK

Biological Activity

[Description]:

Syntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> CaMK

Research Areas >> Neurological Disease

Peptides

[Target]

Km: 12 μM (CaMKII)[1]

[In Vitro]

The sequence of syntide-2 (pro-leu-ala-arg-thr-leu-ser-val-ala-gly-leu-pro-gly-lys-lys) is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the known Ca2+-dependent protein kinases for syntide-2 are determined to be as follows: protein kinase II, 100; protein kinase C, 22; phosphorylase kinase, 2; myosin light chain kinase, 0.005[1].

[References]

[1]. Hashimoto Y, et al. Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide. Arch Biochem Biophys. 1987 Feb 1;252(2):418-25.

[Related Small Molecules]

KN-93 | STO609 | KN-62 | KN-92-hydrochloride | CaMKII-IN-1 | MLCK inhibitor peptide 18 | Autocamtide-2 | A 484954 | Rimacalib | Calmodulin-Dependent Protein Kinase II (290-309) | Metofenazate | NH 125

Chemical & Physical Properties

[ Density]:
1.4 g/cm3

[ Molecular Formula ]:
C₆₈H₁₂₂N₂₀O₁₈

[ Molecular Weight ]:
1507.82000

[ Exact Mass ]:
1506.92000

[ PSA ]:
602.34000

[ LogP ]:
2.04760

[ Index of Refraction ]:
1.629

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3.0