Flusilazole

Names

[ Name ]:
Flusilazole

[Synonym ]:
bis(4-fluorophenyl)-methyl-(1,2,4-triazol-1-ylmethyl)silane
Caswell No. 419K
1-{[Bis(4-fluorophenyl)(methyl)silyl]methyl}-1H-1,2,4-triazole
T5NN DNJ A1-SI-1&R DF&R DF
Fluzilazol
1-[(Bis(4-fluorophenyl)methylsilyl)methyl]-1H-1,2,4-triazole
Sanction
Flusilazol
Punch
1-[[Bis(4-fluorophenyl)methylsilyl]methyl]-1H-1,2,4-triazole
Olymp
Flusilazole
UNII-F3WG2VVD87
MFCD01076615
dpx h6573
1H-1,2,4-Triazole, 1-[[bis(4-fluorophenyl)methylsilyl]methyl]-
Nustar
bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane

Biological Activity

[Description]:

Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. D Fabio Mercado, et al. Reaction Kinetics and Mechanisms of Organosilicon Fungicide Flusilazole With Sulfate and Hydroxyl Radicals. Chemosphere. 2018 Jan;190:327-336.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
392.5±52.0 °C at 760 mmHg

[ Melting Point ]:
51-53ºC

[ Molecular Formula ]:
C₁₆H₁₅F₂N₃Si

[ Molecular Weight ]:
315.393

[ Flash Point ]:
191.2±30.7 °C

[ Exact Mass ]:
315.100342

[ PSA ]:
30.71000

[ LogP ]:
3.84

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.563

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4105000

CHEMICAL NAME :: 1H-1,2,4-Triazole, 1-((bis(4-fluorophenyl)methylsilyl)methyl)-

CAS REGISTRY NUMBER :: 85509-19-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H15-F2-N3-Si

MOLECULAR WEIGHT :: 315.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 674 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,413,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,413,1984

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >5 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C142,1991

Safety Information

[ Symbol ]:

GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H351-H360D-H411

[ Precautionary Statements ]:
P201-P273-P281-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R61;R22;R40;R51/53

[ Safety Phrases ]:
S53-S45-S61

[ RIDADR ]:
UN 2588

[ RTECS ]:
XZ4105000

[ HS Code ]:
2933990015

Customs

[ HS Code ]: 2933990015

[ Summary ]:
2933990015 3-((1h-1,2,4-triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles

Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry.

Anal. Bioanal. Chem 402(8) , 2555-64, (2012)

The liquid chromatography-mass spectrometry (LC-MS) analysis of complex samples such as biological fluid extracts is widespread when searching for new biomarkers as in metabolomics. The success of thi...

Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.).

Commun. Agric. Appl. Biol. Sci. 71(3 Pt B) , 1041-8, (2006)

The present work aimed at the study of the effects of Artea and Punch; two systemic fungicides on durum Wheat (Triticum durum L. cv. GTA dur). Seeds were grown in a medium containing respectively 25, ...

Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure.

Toxicol. Sci. 127(1) , 303-12, (2012)

The zebrafish embryotoxicity test (ZET) is considered a promising alternative model in predictive toxicology. Currently, morphological assessment of the embryo is the main readout for this assay. Howe...