2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine

Names

[ CAS No. ]:
1055035-48-7

[ Name ]:
2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine

[Synonym ]:
6-Chloro-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-2-amine
9H-Purin-2-amine, 6-chloro-9-(3-deoxy-β-D-erythro-pentofuranosyl)-

Biological Activity

[Description]:

2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
681.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H12ClN5O3

[ Molecular Weight ]:
285.69

[ Flash Point ]:
366.2±34.3 °C

[ Exact Mass ]:
285.062866

[ LogP ]:
0.02

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.871

Related Compounds