3′-Azido-2′,3′-dideoxy-5-hydroxyuridine

Names

[ CAS No. ]:
111495-90-0

[ Name ]:
3′-Azido-2′,3′-dideoxy-5-hydroxyuridine

[Synonym ]:
3'-Azido-2',3'-dideoxy-5-hydroxyuridine
Uridine,3'-azido-2',3'-dideoxy-5-hydroxy
3'-N3-5-OH-ddU

Biological Activity

[Description]:

3′-Azido-2′,3′-dideoxy-5-hydroxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H11N5O5

[ Molecular Weight ]:
269.21

[ Exact Mass ]:
269.07600

[ PSA ]:
154.56000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream