3’-Deoxy-3’-fluoro-5-fluorouridine

Names

[ CAS No. ]:
112668-56-1

[ Name ]:
3’-Deoxy-3’-fluoro-5-fluorouridine

[Synonym ]:
3'-Deoxy-3',5-difluorouridine
Uridine, 3'-deoxy-3',5-difluoro-
MFCD28975240

Biological Activity

[Description]:

3’-Deoxy-3’-fluoro-5-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C9H10F2N2O5

[ Molecular Weight ]:
264.18

[ Exact Mass ]:
264.055786

[ LogP ]:
-0.88

[ Index of Refraction ]:
1.583

Related Compounds