2′,3′-Dideoxy-3′-fluoro-5-methylcytidine

Names

[ Name ]:
2′,3′-Dideoxy-3′-fluoro-5-methylcytidine

[Synonym ]:
Cytidine, 2',3'-dideoxy-3'-fluoro-5-methyl-
2(1H)-Pyrimidinone, 4-amino-1-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)-5-methyl-
2',3'-Dideoxy-3'-fluoro-5-methylcytidine

Biological Activity

[Description]:

2′,3′-Dideoxy-3′-fluoro-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
420.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₄FN₃O₃

[ Molecular Weight ]:
243.23

[ Flash Point ]:
207.8±31.5 °C

[ Exact Mass ]:
243.101913

[ LogP ]:
-0.48

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.647