eIF4A3-IN-10

Names

[ CAS No. ]:
1402931-72-9

[ Name ]:
eIF4A3-IN-10

Biological Activity

[Description]:

eIF4A3-IN-10 (compound 58) is a silvestrol (HY-13251) analogue. eIF4A3-IN-10 interferes the assembling of eIF4F translation complex with EC50s of 35 and 100 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-10 can be used for the research of human cancer pathogenesis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

[References]

[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H29NO8

[ Molecular Weight ]:
519.54

Related Compounds