Tau-aggregation-IN-1

Names

[ CAS No. ]:
1619269-19-0

[ Name ]:
Tau-aggregation-IN-1

Biological Activity

[Description]:

Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

D2 Receptor

D3 Receptor


[References]

[1]. Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28(18):115667.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H37N5O2S

[ Molecular Weight ]:
507.69

Related Compounds