2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

Names

[ CAS No. ]:
177980-10-8

[ Name ]:
2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

[Synonym ]:
2'-azido-5'-O-dimethoxytrityl-2'-deoxyuridine
2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
5'-O-(4,4'-dimethoxytrityl)-2'-azido-2'-deoxyuridine
2’-azido-2’-deoxyuridine
5'-O-dimethoxytrityl-2'-azido-2'-deoxyuridine

Biological Activity

[Description]:

2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H29N5O7

[ Molecular Weight ]:
571.58

[ Exact Mass ]:
571.20700

[ PSA ]:
161.76000

[ LogP ]:
2.95246

Related Compounds