2’-Deoxy-2’-fluoro-5-methylcytidine

Names

[ CAS No. ]:
182495-80-3

[ Name ]:
2’-Deoxy-2’-fluoro-5-methylcytidine

[Synonym ]:
Cytidine, 2'-deoxy-2'-fluoro-5-methyl-
2'-Deoxy-2'-fluoro-5-methylcytidine

Biological Activity

[Description]:

2’-Deoxy-2’-fluoro-5-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
495.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H14FN3O4

[ Molecular Weight ]:
259.23

[ Flash Point ]:
253.4±31.5 °C

[ Exact Mass ]:
259.096832

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.675

Related Compounds