Tubulin inhibitor 27

Names

[ CAS No. ]:
184579-57-5

[ Name ]:
Tubulin inhibitor 27

Biological Activity

[Description]:

Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC50 of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

IC50: 25.6 µM (Tubulin polymerisation)[1]


[In Vitro]

Tubulin inhibitor 27 (DYT-1) shows anti-proliferation activity with IC50 values of 6.2 µM and 7.9 µM against K562 and Jurkat, respectively[1].

[In Vivo]

Tubulin inhibitor 27 (DYT-1) shows anti-angiogenesis activity in Zebrafish with an IC50 of 38.4 µM[1].

[References]

[1]. Yao Y, et al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19NO4

[ Molecular Weight ]:
349.38

Related Compounds