NVS-PAK1-C

Names

[ Name ]:
NVS-PAK1-C

Biological Activity

[Description]:

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> PAK

Signaling Pathways >> Cell Cycle/DNA Damage >> PAK

[Target]

PAK1:0.007 μM (Kd)

PAK2:0.4 μM (Kd)

PAK1:5 nM (IC50)

PAK2:270 nM (IC50)

[In Vitro]

NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1].

[References]

[1]. NVS-PAK1-1 A Chemical Probe For PAK1

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃ClF₃N₅O

[ Molecular Weight ]:
465.90

NVS-PAK1-C

Names

Biological Activity

Chemical & Physical Properties

Related Compounds