Antibacterial agent 124

Names

[ CAS No. ]:
2304448-00-6

[ Name ]:
Antibacterial agent 124

Biological Activity

[Description]:

Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: 0.18 μM (SaProRS)[1] Kd: 30.3 nM (SaProRS)[1]


[In Vitro]

Antibacterial agent 124 (Compound 3) shows antibacterial activity with MICs of 1, 1, 4, 1, 1, 2 and 4 μg/mL against E. coli (ATCC25922), S. flexneri (CMCC51572), S. typhi (CMCC50094), MRSA252, MRSA R3708, S. aureus ATCC29213, S. aureus ATCC25923, respectively. And the CC50 to HepG2 is 4.32 μM[1].

[References]

[1]. Cheng B, et al. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J Med Chem. 2022 Nov 17.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H17ClFN3O2

[ Molecular Weight ]:
337.78

Related Compounds