XL 188

Names

[ CAS No. ]:
2305045-76-3

[ Name ]:
XL 188

Biological Activity

[Description]:

XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[In Vitro]

Xl 188 (1-20 μm; 16 h; MCF7 细胞) 促进 USP7 依赖性 HDM2 的丢失和 p53 和 p21 的增加[1]。 Western Blot Analysis[1] Cell Line: MCF7 cells Concentration: 1, 5, 10, and 20μM Incubation Time: 16 hours Result: Had the loss of HDM2 accompanied by an increase in downstream tumor suppressors p21 and p53.

[References]

[1]. Stolte B, et, al. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 Aug 6;215(8):2137-2155.  

Chemical & Physical Properties

[ Molecular Formula ]:
C32H42N6O4

[ Molecular Weight ]:
574.71

Related Compounds