HBV-IN-29

Names

[ CAS No. ]:
2413192-59-1

[ Name ]:
HBV-IN-29

Biological Activity

[Description]:

HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> HBV

[In Vitro]

HBV-IN-29 (ex8; 24 h) 在 HepDES19 细胞中抑制 HBeAg 水平和细胞活力，IC50 值为 1.34 μM。HepDES19 是产生 cccDNA 的细胞系[1]。 HBV-IN-29 (5 days) 以剂量依赖性方式降低 HepDES19 细胞中的 cccDNA 水平[1]。 HBV-IN-29 (9 天; 原代人肝细胞 (PHH)) 具有抗 HBV 作用并抑制 HBeAg，IC50 值为 0.12 μM[1]。

[References]

[1]. Song F, et, al. Flavone compounds for the treatment and prophylaxis of hepatitis b virus disease. WO2020053249.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H19ClO6

[ Molecular Weight ]:
414.84

Related Compounds