AChE/HDAC-IN-1

COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1].

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> HDAC

Signaling Pathways >> Neuronal Signaling >> AChE

HDAC:0.23 nM (IC50)

COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively[1]. COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)[1]. COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity[1].

[1]. Xu A, et al. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorg Chem. 2020 May;98:103721.