CDK8-IN-7

Names

[ CAS No. ]:
2415156-30-6

[ Name ]:
CDK8-IN-7

Biological Activity

[Description]:

CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK8:3.5 nM (Kd)


[References]

[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H40N2

[ Molecular Weight ]:
428.65

Related Compounds